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Frequency distribution of SDPs across different domains of the spike sequence from five human pathogenic β-CoVs. Protein domains are denoted as follows: SS, signal sequence; NTD, N-terminal domain; RBD, receptor binding domain; FP, fusion peptide; HR1, heptad repeat 1; HR2, heptad repeat 2. Interdomain regions are denoted by ID followed by an integer according to the order in which they appear in the sequence. Dashed vertical lines denote S1/S2 subunits boundaries.
