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. 2021 Jan 6;14:1–13. doi: 10.2147/PGPM.S278671

Table 2.

Plasma Lipid, Lipoprotein and Apolipoprotein Biomarkers Among CETP Variants in Patients Treated with Statin

Lipid Biomarkers
Total cholesterol (mmol/L) LDL-C
(mmol/L)
HDL-C
(mmol/L)
Triglycerides
(mmol/L)
Apolipoprotein-AI (mg/dL) Apolipoprotein-B (mg/dL)
CETP rs3764261 (C>A)
 CC (n = 126) 4.87 (4.37–5.34) 2.71 (0.74) 1.26 (1.06–1.55) 1.98 (1.22–2.44) 157.6 (24.2) 90.1 (79.3–106.0)
 CA (n = 140) 4.90 (4.45–5.31) 2.74 (0.87) 1.40 (1.19–1.70) 1.52 (1.11–2.03) 164.3 (27.2) 86.7 (76.5–102.0)
 AA (n = 33) 5.10 (4.75–5.53) 3.02 (0.61) 1.53 (1.39–1.88) 1.40 (1.13–1.78) 171.7 (25.6) 86.0 (77.6–99.5)
p-value 0.180 0.118 <0.001 0.004 0.010 0.597
CETP rs708272 (G>A)
 GG (n = 101) 4.84 (4.39–5.31) 2.72 (0.78) 1.32 (1.11–1.57) 1.79 (1.18–2.27) 158.6 (25.7) 86.4 (78.2–99.8)
 GA (n = 153) 4.95 (4.43–5.54) 2.77 (0.83) 1.35 (1.10–1.66) 1.73 (1.16–2.44) 161.6 (26.6) 88.6 (78.0–108.5)
 AA (n = 45) 4.92 (4.51–5.21) 2.79 (0.72) 1.50 (1.30–1.77) 1.32 (1.05–1.53) 173.0 (23.2) 87.7 (76.5–94.6)
p-value 0.617 0.852 0.006 0.001 0.008 0.398
CETP rs12149545 (G>A)
 GG (n = 193) 4.95 (4.43–5.37) 2.77 (0.77) 1.35 (1.14–1.61) 1.66 (1.16–2.28) 161.7 (25.6) 88.9 (78.8–101.0)
 GA (n = 97) 4.84 (4.42–5.34) 2.74 (0.86) 1.37 (1.17–1.72) 1.58 (1.13–2.27) 162.3 (27.0) 87.1 (75.9–107.0)
 AA (n = 9) 4.95 (4.60–5.44) 2.69 (0.65) 1.71 (1.27–1.98) 1.37 (1.09–1.85) 175.3 (27.2) 84.2 (75.1–98.9)
p-value 0.756 0.937 0.119 0.516 0.312 0.666

Notes: The parametric variables are given as mean (standard deviation) and the nonparametric variables are given as median (interquartile range). All biochemical measures are given in Système International units; conversions to conventional units are as follows: cholesterol (mg/dL), multiply by 38.6; triglycerides (mg/dL), multiply by 88.5.

Abbreviations: LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.