Table 5.
Logistic Regression Analysis Between CETP Genetic Variants, Potential Confounders and Atherogenic Dyslipidemia Complex†
| Dependent Variable | Independent Variables | Logistic Regression‡ | |||||
|---|---|---|---|---|---|---|---|
| All | Men | Women | |||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| Model 1§ | rs3764261 | 2.11 (1.27–3.50) | 0.004 | 2.23 (0.97–5.14) | 0.061 | 2.54 (1.26–5.11) | 0.009 |
| rs708272 | 2.12 (1.29–3.49) | 0.003 | 1.64 (0.68–3.92) | 0.271 | 2.37 (1.24–4.53) | 0.009 | |
| HOMA-IR | 1.47 (1.27–1.71) | <0.001 | 1.32 (1.06–1.64) | 0.013 | 1.57 (1.27–1.92) | <0.001 | |
| Constant | 0.003 | <0.001 | 0.019 | 0.001 | 0.000 | <0.001 | |
| Model 2¶ | rs3764261 and rs708272 | 2.99 (1.78–5.02) | <0.001 | 2.90 (1.16–7.25) | 0.023 | 3.40 (1.72–6.71) | <0.001 |
| HOMA-IR | 1.45 (1.25–1.67) | <0.001 | 1.31 (1.06–1.62) | 0.014 | 1.55 (1.26–1.90) | <0.001 | |
| Constant | 0.008 | <0.001 | 0.010 | <0.001 | 0.001 | 0.001 | |
Notes: †Atherogenic dyslipidemia complex; all features of reduced HDL-C, elevated triglycerides and LDL subclass pattern B. ‡Data are from logistic regression with backward Wald method, adjusted age, BMI, systolic and diastolic blood pressure, HOMA-IR and statin dosage; OR (95% CI): odds ratio (95% confidential interval). §Variables entered in method: rs3764261, rs708272, and rs12149545. ¶Variables entered in method: combination of variants at rs3764261 and rs708272. The detail of the combination groups is shown in supplementary Table 1.