Figure 2.

Three-dimensional peripheral nerve models. Peripheral nerve anatomy informs researchers to create 3D constructs that respect the compartmentalized and polar features found naturally. By containing soma either within restrictive chambers or growing them as spheroids, axon and glial outgrowth can be directed along MEA surfaces to assess electrophysiological function. Sensory neural constructs (top) can integrate a variety of neural subtypes and be used to study satellite glia in neuropathic pain models and the subsequent input into the dorsal horn. Motor neuron constructs (bottom) are currently being integrated into multiorgan NMJ models. Both systems are able to be myelinated by Schwann cells. Nerve fascicle formation, along with perineurial glia, can be studied.