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. 2021 Jan 12;57(2):191–206. doi: 10.1007/s11626-020-00532-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Figure 8. — Peripheral nerve modeling and myelination. (a) Rat primary sensory neuron tissue grown as a spheroid within a growth-restrictive hydrogel can yield (b) induced compound action potentials detected by extracellular field recording. (c, d) Similar spheroids composed of iPSC-derived human neurons can show outgrowth and myelination that can be confirmed by (e) TEM micrographs showing compact myelin rings. Reproduced from Sharma et al. (2019), under Creative Commons license.