Table 2.
Clinical characteristics based on parental history of DM
| No parental history of DM (n=762) | Parental history of DM (n=132) | P value | |
| Basic characteristics | |||
| Age (years) | 51.17±14.09 | 41.70±10.88 | ＜0.001 |
| Men (%) | 502 (65.9) | 95 (72.0) | 0.193 |
| BMI (kg/m2) | 25.49±3.86 | 26.06±3.70 | 0.108 |
| WHR | 0.94±0.06 | 0.95±0.06 | 0.938 |
| SBP (mm Hg) | 135.02±18.51 | 133.40±17.14 | 0.362 |
| DBP (mm Hg) | 83.68±12.81 | 85.00±12.22 | 0.212 |
| Drinking (%) | 202 (26.5) | 38 (28.8) | 0.731 |
| Laboratory data | |||
| Hb (g/L) | 136.71±20.02 | 142.73±20.02 | 0.003 |
| PLT (×109/L) | 218.22±90.17 | 228.58±74.77 | 0.029 |
| FBG (mmol/L) | 8.91±4.38 | 10.84±5.21 | <0.001 |
| HbA1C (%) | 10.03±2.86 | 10.73±2.48 | 0.005 |
| Alb (g/L) | 37.08±4.95 | 38.12±4.44 | 0.057 |
| TC (mmol/L) | 4.56±1.34 | 4.99±1.88 | 0.012 |
| LDL (mmol/L) | 2.86±1.01 | 2.97±1.08 | 0.195 |
| HDL (mmol/L) | 0.98±0.29 | 0.96±0.34 | 0.193 |
| TG (mmol/L) | 2.53±3.0 | 3.72±4.88 | 0.01 |
| sCre (µmol/L) | 69.26±39.93 | 63.83±24.43 | 0.266 |
| HOMA2-IR (%) | 1.43±1.29 | 1.48±1.53 | 0.803 |
| HOMA2-B (%) | 52.41±50.46 | 42.28±46.83 | <0.001 |
| Complications | |||
| DKA | 25 (3.3) | 10 (7.6) | 0.027 |
| HTN | 305 (40.0) | 47 (35.6) | 0.385 |
| Medications | |||
| ACEI (%) | 112 (14.7) | 20 (15.1) | 0.786 |
| ARB (%) | 115 (15.1) | 19 (14.4) | 0.896 |
| Lipid-lowering agents (%) | 479 (62.9) | 85 (64.4) | 0.747 |
HOMA2-B and HOMA2-IR were applied to estimate the function of β-cell and insulin resistance, respectively, which were calculated using fasting plasma glucose and C-peptide.
*Refers to p<0.05.
ACEI, ACE inhibitor; Alb, albumin; ARB, angiotensin receptor blocker; BMI, body mass index; DBP, diastolic blood pressure; DKA, diabetic ketoacidosis; DM, diabetes mellitus; FBG, fasting blood glucose; Hb, haemoglobin; HbA1C, glycosylated haemoglobin; HDL, high-density lipoprotein; HOMA2-B, homoeostatic model assessment 2-B; HOMA2-IR, homoeostatic model assessment 2-insulin resistance; HTN, hypertension; LDL, low-density lipoprotein; PLT, platelet; SBP, systolic blood pressure; sCre, serum creatinine; TC, total cholesterol; TG, triglyceride; WHR, waist-to-hip ratio.