Table 3.
Clinical characteristics based on sibling history of DM
| No sibling history of DM (n=806) | Sibling history of DM (n=88) | P value | |
| Basic characteristics | |||
| Age (years) | 49.09±14.29 | 56.05±9.86 | ＜0.001 |
| Men (%) | 555 (68.9) | 42 (47.7% | ＜0.001 |
| BMI (kg/m2) | 25.69±3.86 | 24.49±3.48 | 0.011* |
| WHR | 0.95±0.07 | 0.94±0.06 | 0.059 |
| SBP (mm Hg) | 134.99±18.26 | 132.89±18.87 | 0.413 |
| DBP (mm Hg) | 83.88±12.79 | 83.84±12.21 | 0.992 |
| Drinking (%) | 218 (27) | 22 (25) | 0.819 |
| Laboratory data | |||
| Hb (g/L) | 137.87±19.98 | 135.17±18.47 | 0.109 |
| PLT (×109/L) | 219.13±88.22 | 225.44±87.34 | 0.57 |
| FBG (mmol/L) | 9.16±4.62 | 9.57±3.97 | 0.079 |
| HbA1C (%) | 10.10±2.86 | 10.43±2.43 | 0.232 |
| Alb (g/L) | 37.27±4.95 | 36.88±4.36 | 0.247 |
| TC (mmol/L) | 4.62±1.44 | 4.70±1.45 | 0.786 |
| LDL (mmol/L) | 2.86±1.04 | 2.99±0.88 | 0.196 |
| HDL (mmol/L) | 0.98±0.30 | 0.99±0.24 | 0.366 |
| TG (mmol/L) | 2.75±3.42 | 2.28±2.88 | 0.358 |
| sCre (µmol/L) | 68.99±39.27 | 63.56±23.95 | 0.12 |
| HOMA2-IR (%) | 1.45±1.38 | 1.31±0.86 | 0.639 |
| HOMA2-B (%) | 52.37±51.80 | 37.81±27.09 | 0.062 |
| Complications | |||
| DKA | 30 (3.7%) | 5 (5.7%) | 0.379 |
| HTN | 314 (39.0%) | 38 (43.2%) | 0.491 |
| Medications | |||
| ACEI (%) | 117 (14.5) | 9 (10.2) | 0.334 |
| ARB (%) | 117 (14.5) | 17 (19.3) | 0.269 |
| Lipid-lowering agents (%) | 506 (62.8) | 58 (65.9) | 0.642 |
HOMA2-B and HOMA2-IR were applied to estimate the function of β-cell and insulin resistance, respectively, which were calculated using fasting plasma glucose and C-peptide.
*Refers to p<0.05.
ACEI, ACE inhibitor; Alb, albumin; ARB, angiotensin receptor blocker; BMI, body mass index; DBP, diastolic blood pressure; DKA, diabetic keto acidosis; DM, diabetes mellitus; FBG, fasting blood glucose; Hb, haemoglobin; HbA1C, glycosylated haemoglobin; HDL, high-density lipoprotein; HOMA2-B, homoeostatic model assessment 2-B; HOMA2-IR, homoeostatic model assessment 2-insulin resistance; HTN, hypertension; LDL, low-density lipoprotein; PLT, platelet; SBP, systolic blood pressure; sCre, serum creatinine; TC, total cholesterol; TG, triglyceride; WHR, waist-to-hip ratio.