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. 2021 Jan 11;11(1):e041072. doi: 10.1136/bmjopen-2020-041072

Table 4.

Correlation between family history of diabetes and clinical characteristics

Parental history of DM Sibling history of DM
r P a-r a-P r P a-r a-P
Sex 0.046 0.171 −0.134 <0.001
Age −0.237 <0.001 0.125 <0.001
SBP −0.031 0.357 −0.031 0.357 −0.037 0.266 −0.034 0.319
DBP 0.032 0.334 0.002 0.958 −0.015 0.653 −0.002 0.951
BMI 0.06 0.077 −0.088 0.01
TG 0.075 0.028 0.026 0.45 −0.018 0.6 0.011 0.753
TC 0.07 0.041 0.054 0.125 0.038 0.273 0.045 0.204
HDL −0.063 0.066 −0.04 0.256 0.019 0.581 −0.031 0.383
LDL 0.045 0.179 0.03 0.376 −0.011 0.741 −0.021 0.542
FBG 0.141 <0.001 0.119 0.001* 0.054 0.109 0.075 0.028
HbA1C 0.101 0.003 0.071 0.038 0.005 0.87 0.01 0.777
HOMA2-IR (%) −0.022 0.521 −0.039 0.275 −0.015 0.673 0.008 0.83
HOMA2-B (%) −0.093 0.007 −0.066 0.061 −0.07 0.044 −0.096 0.007
DKA 0.079 0.019 0.05 0.146 0.03 0.369 0.05 0.142

a-r and a-p: correlation adjusted for sex, age and BMI.

HOMA2-B and HOMA2-IR were applied to estimate the function of β-cell and insulin resistance, respectively, which were calculated using fasting plasma glucose and C-peptide.

*Refers to p<0.05.

BMI, body mass index; DBP, diastolic blood pressure; DKA, diabetic keto acidosis; DM, diabetes mellitus; FBG, fasting blood glucose; HbA1C, glycosylated haemoglobin; HDL, high-density lipoprotein; HOMA2-B, homoeostatic model assessment 2-B; HOMA2-IR, homoeostatic model assessment 2-insulin resistance; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; WHR, waist-to-hip ratio.