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. 2021 Jan 8;14:145–155. doi: 10.2147/OTT.S286408

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© 2021 Wang et al.

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ALYREF is regulated by MYC at RNA levels. (A) The ChIP sequencing data showed the enrichment of MYC, PolII, H3K4me3 and H3K27Ac signaling at ALYREF promoter in HepG2 cells. (B) ChIP-qPCR validation for MYC at ALYREF promoter in GBM cells. (C) U251 and U-118 MG cells were transfected with GFP or MYC overexpression plasmids, and the relative luciferase activity of ALYREF promoter was measured. (D) The relative ALYREF mRNA levels transfected with GFP or MYC overexpression plasmids in U251 and U-118 MG cells. The results are shown as the mean ± SEM, n = 3 in (B–D). *P < 0.05; **P < 0.01.