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. 2021 Jan 8;14:145–155. doi: 10.2147/OTT.S286408

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© 2021 Wang et al.

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ALYREF activates Wnt/β-catenin signaling pathway and control MYC mRNA levels. (A) The heatmap represents the cancer hallmarks enriched in high or low-ALYREF expressional group of TCGA-GBM cohort. (B) GSEA analysis for cancer hallmarks in ALYREF high expressed group of TCGA-GBM cohort. (C) KEGG pathway analysis for upregulated ALYREF group in TCGA-GBM cohort. (D) The relative target genes mRNA levels of Wnt/β-catenin signaling pathway transfected with control or ALYREF siRNAs in GBM cell. Data (n = 3) was represented as the mean ± SEM in (D). *P < 0.05.