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. 2021 Jan 8;14:145–155. doi: 10.2147/OTT.S286408

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© 2021 Wang et al.

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ALYREF controls MYC mRNA stability in GBM cells. (A) The CLIP sequencing data showed the enrichment of ALYREF at 3ʹ-UTR of MYC in HeLa cell. (B) iCLIP-qPCR validation for ALYREF binding to MYC mRNA in GBM cells. (C) The relative luciferase activity of 3ʹ-UTR of MYC transfected with control or ALYREF siRNAs in U251 and U-118 MG cells. (D) The relative MYC mRNA levels in U251 and U-118 MG cells transfected with control or ALYREF siRNAs and treated with actinomycin D. (E) The colony assay transfected with ALYREF, ALYREF plus MYC overexpression plasmids or negative siRNA in U251 and U-118 MG cells. (F) The expressional correlation of ALYREF with MYC in TCGA-GBM cohort. The results (n = 3) were represented as the mean ± SEM in (B–E). *P < 0.05; **P < 0.01.