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. 2021 Jan 8;16:57–70. doi: 10.2147/CIA.S285689

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© 2021 Al-Rawaf et al.

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Metabolic changes in the DPP4 activity, BDNF, SIRT-1, and apoptotic genes Bcl-2, Bax, and caspase-3 in healthy control (n=80) and older adults with MCI (n=70). (A–D). The results showed that the levels of BDNF, SIRT-1 significantly reduced and the levels of DPP4 activity significantly increased in older subjects with MCI compared to healthy controls (A–C). In addition, the expression of apoptotic genes was significantly reported in all subjects. In Older adults with MCI, the expression levels of both Bax and caspase-3 genes significantly (p=0.001) increased, and the expression levels of Bcl-2 gene significantly (p=0.01) reduced in comparison with the results of healthy controls (D). Significance of the comparison was evaluated by Mann–Whitney–Wilcoxon test and sample t-test, ^**p≤ 0.01 ^***p≤ 0.001.

Abbreviation: MCI, mild cognitive impairment.