. 2021 Jan 8;16:57–70. doi: 10.2147/CIA.S285689

Table 4.

Correlations Between DPP4 Activities, BDNF, SIRT-1, Celluar Oxidative Stress, Apoptosis, and Relative Expression of miRNAs vs Cognitive Parameters

Characteristics	Cognitive Function (n=70)
	MMSE^a		MoCA^a		ADL^a		Memory Scores^a
	r	P	r	P	r	P	r	P
DPP4 activity (nmol/min/mL)	−0.320	<0.001	−0.291	< 0.001	−0.31	<0.001	−0.24	<0.001
BDNF (ng/mL)	0.192	<0.001	0.23	<0.001	0.18	<0.001	0.15	<0.001
SIRT1(ng/mL)	0.31	<0.001	0.45	<0.001	0.27	<0.001	0.34	<0.001
NO	0.35	<0.001	0.28	<0.001	0.29	<0.001	0.47	<0.001
MDA	0.23	<0.001	0.36	<0.001	0.51	<0.001	0.14	<0.001
CAT	−0.32	<0.001	−0.39	<0.001	−0.25	<0.001	−0.31	<0.001
SOD	−0.54	0.001	−0.48	<0.001	−0.37	<0.001	−0.43	<0.001
Bax	0.21	<0.001	0.18	<0.001	0.26	<0.001	0.26	<0.001
Bcl-2	−0.45	<0.001	−0.49	<0.001	−0.53	<0.001	−0.78	<0.001
Caspase-3	0.48	<0.001	0.21	<0.001	0.23	<0.001	0.19	<0.001
miR-124a	0.251	<0.001	0.362	<0.001	0.182	<0.001	0.135	<0.001
miR-483-5p	0.314	<0.001	0.217	<0.001	0.321	<0.001	0.158	<0.001
miR-142-3p	−0.242	<0.001	−0.342	<0.001	−0.124	<0.001	−0.314	<0.001
miR-125b	−0.254	<0.001	−0.227	<0.001	−0.351	<0.001	−0.318	<0.001

Note: ^aP-value determined by partial correlation analysis with respect to the DPP4 activity, BDNF, SIRT-1, cellular oxidative stress, apoptosis, and relative expression of miRNAs adjusted for age, BMI, gender, education level, exercise levels, and working.