TABLE 1.

FCNs do not Cause Disseminated Intravascular Coagulation

	Saline (24 h)	FCNs (24 h)	Saline (48 h)	FCNs (48 h)
PT (s) (normal 9–12)	11.4 ± 0.17	11.7 ± 0.87	11.5 ± 0.36	11.1 ± 0.33
aPTT (s) (normal 20–30)	23.6 ± 0.80	23.9 ± 2.27	21.5 ± 2.01	24.7 ± 3.10
TT (s) (normal 16–22)	20.1 ± 1.90	20.4 ± 2.80	18.5 ± 1.26	16.9 ± 1.47
Fibrinogen (mg/dl) (normal 100–200)	152.8 ± 19.4	116.2 ± 32.5	116.0 ± 41.5	172.6 ± 29.2
D-dimer (mcg/ml) (normal 0.22)	0.22 ± <0.0	0.22 ± <0.0	0.22 ± <0.0	0.22 ± <0.0

Notes. To evaluate safety, blood was drawn from mice treated with FCNs and examined for evidence of DIC. No differences or variations from normal (32, 33) were observed in prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, or D-dimer levels at 24 and 48 h after FCN injection. The mean values of five replicates and standard deviations are shown.