Table 3.
Repeatability of Macular Vascular Density Measurement Obtained Using OCTA for Eyes with and without CME or Retinal Vasculopathy. (A) 3x3 mm OCTA Scans. (B) 6x6 mm OCTA Scans
| A. Repeatability of Macular Vascular Density Measurement for 3x3 mm OCTA Scans | ||||||
| 3x3 mm Scan | CME (n=16) | No CME (n=38) | Vasculopathy without CME (n=15) | |||
| CV, Mean (SD)% |
ICC (95% CI) |
CV, Mean (SD)% |
ICC (95% CI) |
CV, Mean (SD)% |
ICC (95% CI) |
|
| SCP | ||||||
| ETDRS | 4.5 (3.3) | 0.883 (0.687–0.959) |
3.3 (2.4) |
0.902 (0.820–0.948) |
3.4 (2.6) |
0.909 (0.752–0.969) |
| Fovea | 11.5 (7.2) | 0.885 (0.702–0.958) |
9.4 (9.5) |
0.908 (0.831–0.951) |
10.2 (9.6) |
0.914 (0.764–0.970) |
| 3 mm inner ring | 4.1 (2.8) | 0.903 (0.737–0.966) |
3.3 (2.5) |
0.899 (0.815–0.946) |
3.4 (2.6) |
0.912 (0.758–0.969) |
| DCP | ||||||
| ETDRS | 4.0 (4.1) | 0.188 (−0.323–0.615) |
3.0 (2.6) |
0.806 (0.657–0.894) |
3.2 (2.7) |
0.858 (0.630–0.950) |
| Fovea | 9.9 (15.7) | 0.747 (0.414–0.904) |
4.8 (2.9) |
0.953 (0.912–0.976) |
6.2 (3.4) |
0.940 (0.832–0.980) |
| 3 mm inner ring | 4.5 (4.6) | 0.804 (0.511–0.930) |
3.1 (2.9) |
0.783 (0.620–0.881) |
3.2 (3.1) |
0.843 (0.595–0.944) |
| cDCP | ||||||
| ETDRS | 13.4 (35.6) | 0.342 (−0.187–0.717) |
8.2 (7.4) |
0.877 (0.776–0.934) |
6.8 (5.1) |
0.933 (0.814–0.977) |
| Fovea | 10.7 (7.2) | 0.840 (0.600–0.941) |
13.5 (11.7) |
0.613 (0.369–0.779) |
14.5 (12.7) | 0.581 (0.118–0.837) |
| 3 mm inner ring | 4.3 (3.9) | 0.836 (0.580–0.942) |
7.6 (7.2) |
0.666 (0.443–0.811) |
6.4 (4.9) |
0.772 (0.446–0.917) |
| cICP | ||||||
| ETDRS | 5.7 (3.2) |
0.746 (0.316–0.920) |
7.2 (7.1) |
0.777 (0.525–0.895) |
5.7 (5.9) |
0.857 (0.488–0.969) |
| Fovea | 3.6 (3.8) |
0.944 (0.825–0.983) |
9.6 (7.3) |
0.800 (0.608–0.901) |
9.8 (5.3) |
0.883 (0.516–0.976) |
| 3 mm inner ring | 6.1 (3.5) |
0.749 (0.322–0.921) |
7.3 (7.1) |
0.771 (0.537–0.889) |
6.3 (6.4) |
0.827 (0.399–0.962) |
| FAZ size | 24.2 (48.2) | 0.958 (0.885–0.985) |
7.5 (20.4) |
0.884 (0.787–0.938) |
15.2 (31.2) | 0.800 (0.502–0.928) |
| B. Repeatability of Macular Vascular Density Measurement for 6x6 mm OCTA Scans | ||||||
|---|---|---|---|---|---|---|
| 6x6 mm Scan | CME (n=12) | No CME (n=35) | Vasculopathy without CME (n=13) | |||
| CV, Mean (SD)% | ICC (95% CI) |
CV, Mean (SD)% | ICC (95% CI) |
CV, Mean (SD)% | ICC (95% CI) |
|
| SCP | ||||||
| ETDRS | 4.4 (2.9) | 0.837 (0.503–0.953) |
2.8 (2.5) |
0.936 (0.877–0.967) |
2.8 (1.6) |
0.947 (0.836–0.984) |
| Fovea | 16.1 (8.0) | 0.723 (0.282–0.911) |
8.4 (8.2) |
0.937 (0.878–0.968) |
9.1 (5.2) |
0.939 (0.812–0.981) |
| 3 mm inner ring | 4.5 (2.9) | 0.859 (0.584–0.957) |
3.4 (2.7) |
0.923 (0.852–0.960) |
4.3 (2.6) |
0.914 (0.744–0.973) |
| 6 mm outer ring | 16.1 (39.6) | 0.257 (−0.345–0.709) |
3.1 (2.8) |
0.925 (0.857–0.961) |
3.3 (2.1) |
0.917 (0.752–0.974) |
| DCP | ||||||
| ETDRS | 3.5 (2.1) | 0.928 (0.757–0.980) |
3.6 (3.3) |
0.844 (0.712–0.918) |
4.9 (4.1) |
0.822 (0.514–0.942 |
| Fovea | 15.6 (16.6) | 0.399 (−0.198–0.780) |
5.3 (4.5) |
0.916 (0.841–0.957) |
7.1 (5.7) |
0.837 (0.551–0.947) |
| 3 mm inner ring | 3.6 (2.3) | 0.902 (0.697–0.971) |
2.3 (2.1) |
0.900 (0.810–0.948) |
2.9 (2.6) |
0.898 (0.699–0.968) |
| 6 mm outer ring | 3.7 (2.3) | 0.912 (0.709–0.976) |
4.5 (4.1) |
0.816 (0.665–0.902) |
5.6 (3.5) |
0.793 (0.452–0.932) |
| cDCP | ||||||
| ETDRS | 7.3 (9.9) | 0.574 (−0.430–0.874) |
4.1 (3.4) |
0.492 (0.183–0.712) |
3.8 (3.5) |
0.427 (−0.198–0.805) |
| Fovea | 25.6 (22.3) | 0.058 (−0.511–0.592) |
10.4 (10.4) |
0.736 (0.5537–0.857) |
12.5 (11.4) | 0.499 (−0.046–0.815) |
| 3 mm inner ring | 7.6 (12.9) | 0.400 (−0.197–0.780) |
4.2 (3.0) |
0.624 (0.371–0.791 |
3.4 (2.3) |
0.701 (0.269–0.898) |
| 6 mm outer ring | 18.3 (39.6) | 0.216 (−0.383–0.687) |
4.3 (3.6) |
0.509 (0.216–0.718) |
4.1 (4.1) |
0.483 (−0.67–0.808) |
| cICP | ||||||
| ETDRS | 5.9 (6.2) |
0.774 (0.376–0.933) |
5.5 (5.1) |
0.338 (−0.002–0.611) |
6.7 (7.0) |
0.493 (−0.097–0.850) |
| Fovea | 18.1 (22.2) |
0.256 (−0.406–0.730) |
7.7 (5.9) |
0.735 (0.517–0.863) |
12.4 (7.7) |
0.147 (−0.231–0.640) |
| 3 mm inner ring | 9.6 (10.1) |
0.451 (−0.074–0.806) |
5.2 (4.6) |
0.566 (0.276–0.763) |
6.6 (5.3) |
0.525 (−0.055–0.861) |
| 6 mm outer ring | 6.5 (6.1) |
0.769 (0.332–0.937) |
5.1 (5.2) |
0.416 (0.095–0.663) |
7.3 (8.0) |
0.430 (−0.135–0.822) |
| FAZ size | 19.1 (25.0) | 0.895 (0.677–0.969) | 6.5 (7.3) | 0.957 (0.916–0.978) | 7.8 (8.0) | 0.935 (0.792–0.981) |
Abbreviations: CV, coefficient of variation; ICC, intraclass coefficient; SCP, superficial capillary plexus; DCP, deep capillary plexus; cDCP, custom-segmented deep capillary plexus; FAZ, foveal avascular zone, cICP, custom-segmented intermediate capillary plexus; CME, cystoid macular edema; ETDRS, early treatment of diabetic retinopathy study macular region 6 mm diameter centered in the fovea.