Fig 1.

Pearson correlation coefficients between experimentally-determined and calculated values of changes in protein stability (ΔΔG) for PremPS performing three types of cross-validation (A) and leave-one-protein-out validation on S5296 (B), and tested on the dataset of S^sym (C) and S921 (D), respectively. PremPS^M: the model was retrained after removing the overlapped mutations including their corresponding reverse mutations with the dataset of S^sym from the training dataset. See also S2 Fig and S1 and S4 Tables.