Table 3. PremPS’ performance on four datasets.

Leave-one-protein-out validation (CV4) results are shown for S2297 and RS2297. More details are provided in S9 Table.

Dataset	R	RMSE
S2297	0.57	1.23
RS2297	0.59	1.23
S824	0.74	1.48
RS824	0.71	1.61

R: Pearson correlation coefficient between experimental and predicted ΔΔG values. RMSE (kcal mol^-1): root-mean square error. No statistically significantly differences in correlation coefficient are observed between S2297 and RS2297, and S824 and RS824 (Fisher1925 test).