Table 2.

Results of multivariate Cox proportional-hazards regression analyzing the effect of baseline variables on in-hospital death in all patients with COVID-19

Mode	HR (95%CI)	P
Not adjusted CD4+T level, lower vs. higher	13.659 (3.235–57.671)	< 0.001
Mode 1
CD4+T cell level, lower vs. higher	14.182 (1.884–106.786)	0.010
Sex, male vs. female	1.383 (0.561–3.406)	0.481
Age, per 1 year	1.093 (1.052–1.135)	< 0.001
Temperature, per 1 °C	0.777 (0.445–1.354)	0.372
Mode 2
CD4+T cell level, lower vs. higher	13.631 (3.190–58.243)	< 0.001
Hypertension, yes vs. no	5.823 (2.595–13.070)	< 0.001
Diabetes, yes vs. no	0.824 (0.322–2.113)	0.688
Shortness of breath, yes vs. no	7.848 (2.942–20.934)	< 0.001
Mode 3
CD4+T cell level, lower vs. higher	8.170 (1.877–35.566)	0.005
WBC, per 1×109/L	1.294 (1.193–1.404)	< 0.001
PLT, per 1×109/L	0.992 (0.987–0.997)	0.003
Cr, per 1 umol/L	1.002 (0.995–1.009)	0.576
Mode 4
CD4+T cell level, lower vs. higher	10.644 (2.439–46.458)	0.002
Hs-CRP, per 1 mg/L	0.989 (0.974–1.005)	0.193
PCT, per 1 ng/ml	1.017 (0.925–1.118)	0.724
D-dimer, per 1 mg/L	1.028 (1.018–1.038)	< 0.001
Mode 5
CD4+T cell level, lower vs. higher	13.650 (1.976–94.279)	0.008
CD8+T cell level, lower vs. higher	3.159 (0.853–11.707)	0.085
CD4/CD8 ratio, per 1 unit	1.422 (1.105–1.830)	0.006
LYM level, lower vs. higher	0.996 (0.306–3.243)	0.994
Mode 6
CD4+T cell level, lower vs. higher	7.656 (1.610–36.396)	0.010
Age, per 1 year	1.074 (1.034–1.115)	< 0.001
Hypertension, yes vs. no	2.031 (0.766–5.386)	0.154
Shortness of breath, yes vs. no	3.435 (1.167–10.114)	0.025
WBC, per 1×109/L	1.224 (1.097–1.366)	< 0.001
PLT, per 1× 109/L	0.996 (0.991–1.001)	0.149
D-dimer, per 1 mg/L	0.997 (0.992–1.002)	0.207
CD4/CD8 ratio, per 1 unit	1.106 (0.793–1.542)	0.552

Abbreviations: WBC white blood cell, PLT platelet, Cr creatinine, Hs-CRP hypersensitive C-reactive protein, PCT procalcitonin, LYM lymphocyte