Highlights	Class of Recommendation	Level of Evidence
•Five forms of PA due to germ-line mutations have been identified.	I	A
•Patients diagnosed with PA at a young age, with a family history of PA and/or early cerebro- and cardio-vascular events should be considered to have germ-line mutations.	I	B
•These patients should be tested for germ-line mutations.	I	B
•Genetic testing allows a specific and more effective treatment in FH-I.	I	B