Highlights	Class of Recommendation	Level of Evidence
•AVS-guided laparoscopic adrenalectomy is the best treatment for unilateral PA.	II	B
•In preparation for surgery, arterial hypertension, hypokalemia, and obesity should be corrected.	II	C
•Transient post-operative hyperkalemia and increased serum creatinine may follow adrenalectomy in some patients.	II	B
•In bilateral PA patients and in those with AVS-diagnosed unilateral PA cannot be candidate for surgery or other operative interventions, MRAs, alone or in combination with other antihypertensive agents, are recommended in order to normalize BP and obtain normokalemia.	II	A
•Medical treatment should be based on MRAs including spironolactone, canrenone, potassium canrenoate, and eplerenone.	II	B