Highlights	Class of Recommendation	Level of Evidence
•Currently, hypokalemia is absent in the majority of PA patients and, therefore, cannot be used as a screening test.	II	B
•Withdrawal of all antihypertensive medications is not recommended for measurement of the ARR.	III	C
•Patients should be worked-up for PA under proper conditions (i.e. normokalemia and switching to none interfering treatment).	II	A
•In patients with marked hypokalemia and/or drug-resistant hypertension MRAs can be administered during screening.	II	B
•The finding of high PAC and low renin while on drugs expected to rise renin and lower PAC, can allow the diagnosis of PA.	II	B
•The clinical use of ARR requires careful considerations to the actual values of PAC and renin, and to the factors that can influence these values.	II	B