Table 2.
Prevalence of initial orthostatic hypotension, classic orthostatic hypotension and orthostatic intolerance symptoms, stratified by initial orthostatic hypotension definition.
| First author, year | N | OH (%) |
Symptoms (%) |
COH def. | ||||
|---|---|---|---|---|---|---|---|---|
| IOH | COH | Total | IOH | COH | No OH | |||
|
IOH within 15s | ||||||||
| De Bruine, 2017 [25] | Total, n = 24 | 54.2 | 100 | – | – | – | – | COH ex. First 15s |
| Normal, n = 24 | – | 100 | 54.2 | – | 54.2 | – | ||
| Slow, n = 24 | – | 100 | 41.7 | – | 41.7 | – | ||
| Fast, n = 24 | – | 100 | 75 | – | 75 | – | ||
| De Bruine, 2019 [26] | Total, n = 58 | 41.1 | 84.5 | – | – | – | – | COH ex. First 15s |
| Hayakawa, 2015 [3] | Total, n = 199 | 62.5 | 6b | – | – | – | – | COH |
| McDonald, 2017 [23] | Total, n = 297 | 16.2 | 81 | 4.5 | – | – | – | COH |
| Falls, n = 30 | – | 82 | 17 | – | – | – | ||
| No falls, n = 49 | – | 87 | 14 | – | – | – | ||
| Mol, 2018 [27] | Total, n = 109 | 29.4 | 76.1 | – | – | – | – | COH |
| Saedon, 2016 [29] | Total, n = 267 | 16 | 54 | – | – | – | – | COH |
| Saedon, 2020 [24] | Total, n = 1245 | 24.9 | 62 | – | – | – | – | COH, ex. IOH within 15s |
|
IOH within 15s + symptoms | ||||||||
| Breeuwsma, 2017 [19] | Sitting, n = 104 | 5.8 | 67.3 | 12.5 | 100 | 6.7a | – | COH ex. First 15s |
| Standing, n = 104 | 16.3 | 66.3 | 22.1 | 100 | 5.8a | – | ||
| Romero-Ortuno, 2011 [17] | Total, n = 442 | 19.2 | 94.1 | 19.3 | 100 | 29.5 | – | COH |
| Cluster 1, n = 112 | 3.6 | 80.4 | 17.9 | 100 | 14.3a | – | ||
| Cluster 2, n = 238 | 17.4 | 98.3 | 27.5 | 100 | 10.1a | – | ||
| Cluster 3, n = 92 | 43.5 | 100 | 44.6 | 100 | 1.2a | – | ||
|
IOH within 15 s, correcting within 30-60 s | ||||||||
| McJunkin, 2015 [2] | Total, n = 115 | 3.5 | 12.2 | 17.4 | 50 | 14.3 | 14.4 | COH, sust. |
|
IOH within 30 s | ||||||||
| Shaw, 2019 [28] | Total, n = 116 | 11.5 | 44 | – | – | – | – | COH |
|
OH within 1 min | ||||||||
| Bengtsson-Lindberg, 2015 [18] | Total, n = 204 | 10.9 | 34 | 27 | 24 | 40 | 19 | COH |
| Control, n = 50 | 0 | 13 | 2 | – | – | 2.3 | ||
| DLB, n = 50 | 34 | 70 | 40 | – | – | 20 | ||
| AD, n = 50 | 4 | 33 | 28 | – | – | 29 | ||
| Advasc, n = 54 | 6 | 45 | 37 | – | – | 33.3 | ||
OH: orthostatic hypotension. IOH: initial orthostatic hypotension. COH: classical orthostatic hypotension. COH def.: classical orthostatic hypotension definition. DLB: Dementia with Lewy bodies. AD: Alzheimer's disease. ADvasc: Alzheimer's disease with vascular components.
Symptoms experienced not specific to COH diagnosis or no OH diagnosis.
Systolic blood pressure range of deficit >30% from baseline at 60 s, (%). COH ex. First 15s: COH excluding the first 15 s after postural change. COH sust.: COH with sustained low blood pressure. COH, ex. IOH within 15s: COH without IOH occurring in the first 15 s post postural change.