Figure 2. Post-transplantation, pre-ATI CD4⁺ and CD8⁺ T cell dynamics.

(A) Empirical data for peripheral CD4⁺ CCR5⁺ (top row), CD4⁺CCR5^- (middle row), and CD8⁺ T cell counts (bottom row) for control (blue), wild-type (red), and ΔCCR5 (green) transplantation groups. Each data point shape and color is a different animal sampled over time. (B) Distributions of blood CD4⁺ and CD8⁺ T cell counts for weeks 0, 10, and 25 after transplantation (p-values calculated with pairwise Mann-Whitney test with Bonferroni correction comparing control group with transplant groups. ^*p<0.05, ^**p<0.01 and ^***p<0.001). (C) Expansion-rate estimates of CD4⁺CCR5⁺, CD4⁺CCR5^-, and CD8⁺ T cells (p-values calculated with paired Mann-Whitney test with Bonferroni correction comparing expansion rates of CD4⁺CCR5^- with CD4⁺CCR5⁺ and CD8⁺ in transplant groups. ^**p<0.01 for both). Colors for boxplots in B and C are matched to A (blue: control, red: wild-type-transplantation, and green: ΔCCR5-transplantation groups).

Figure 2—figure supplement 1. CD4⁺ and CD8⁺ T cell levels pre-ATI in control group (n = 5) at times relative to post-transplantation in WT and ΔCCR5 transplant groups.

Range of blood (A) CD4⁺ and (B) CD8⁺ T cell counts using all data points for the period before ATI in control animals (p-value calculated with a paired t-test for averaged measurements from a time relative to infusion in transplanted animals and before ATI).