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. 2020 Nov 20;12(24):25452–25468. doi: 10.18632/aging.104146

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Copyright: © 2020 Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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OSMI-1 abolished SPC induced activation in OGT mediated O-GlcNAcylation and reduction in p-RIPK3, p-MLKL. (A, B) Expressions of O-GlcNAc, OGT and OGA in all groups were analyzed by Western Blot. Representative protein images and quantitative analysis were shown. n=3/group. (C, D) Representative protein images and quantitative analysis of p-RIPK1, p-RIPK3, and p-MLKL in all groups were presented. n=3/group. OSMI-1, the OGT inhibitor; DMSO, the OSMI-1 solvent. The columns and errors bars represent means ± SD. * P < 0.05 vs. SHAM group; # P < 0.05 vs. IR group; & P < 0.05 vs. SPC group.