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. 2020 Nov 24;12(24):24604–24622. doi: 10.18632/aging.104196

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Copyright: © 2020 Khor and Cai.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Lifespan effects of Toll pathway inhibition in IPCs and neuroblasts are stage-dependent. (A, B) Survival, median lifespan, and 10% max lifespan of UAS-Cactus/+;elav-Gal4/+ males (blue), tub-Gal80^ts/UAS-Cactus;elav-Gal4/+ males (purple), and UAS-Cactus/+;+/+ (black) control males (A). Corresponding lifespan analysis for females (B). (C, D) Survival, median lifespan, and 10% max lifespan of dilp5-Gal4/UAS-Cactus;+/+ males (brown), dilp5-Gal4/UAS-Cactus;tub-Gal80^ts/+ males (purple), and UAS-Cactus/+;+/+ (black) control males (C). Corresponding lifespan analysis for females (D). (E, F) Survival, median lifespan, and 10% max lifespan of wor-Gal4/UAS-Cactus;+/+ males (orange), wor-Gal4/UAS-Cactus;tub-Gal80^ts/+ males (red), and UAS-Cactus/+;+/+ (black) control males (E). Corresponding lifespan analysis for females (F). Data information: statistics for curve comparisons are shown in the figure. Error bars represent mean ± SEM. **** p<.0001 (log-rank test). n = at least 100 flies for each genotype in lifespan experiments.