Table 4. Results of trim and fill method and publication bias (binary variable).

Variable	No. of Studies	OR(95%CI)	Observed + Imputed	P-Value	Method
			OR(95%CI)
Fever	11	0.84(0.57,1.21)	1.03(0.71,1.49)	0.18	Harbord
Cough	12	0.87(0.56,1.35)	0.87(0.56,1.35)	0.90	Harbord
Diabetes	18	2.51(1.86,3.35)	2.51(1.86,3.35)	0.35	Harbord
Hypertension	15	2.39(1.95,2.89)	2.39(1.95,2.89)	0.32	Harbord
Malignancies	12	2.36(1.68,3.29)	2.24(1.61,3.12)	0.85	Harbord
COPD	11	1.99(1.51,2.64)	1.95(1.47,2.58)	0.18	Harbord
Cardiovascular disease	17	2.92(2.08,4.10)	2.92(2.08,4.10)	0.29	Harbord
Cerebrovascular disease	10	2.69(2.01,3.60)	2.44(1.85,3.21)	0.01	Harbord
Chronic renal disease	15	3.03(1.77,5.16)	3.03(1.77,5.16)	0.83	Harbord