Table 3. Major signs and clinical symptom changes showing a positive percentage over time.

	In 2009 (%)	In 2020 (%)	P value
Sex (male)	46.6	55.0	0.388
Graying of hair, hair loss	98.1	97.5	1.000
Cataracts	92.5	100	0.124
Skin changes	97.4	97.5	1.000
Intractable skin ulcers	87.5	67.5	<0.01
Soft-tissue calcification	76.7	87.5	0.048
Bird-like face	96.1	90.0	0.220
High-pitched voice	88.0	87.5	1.000
Diabetes, impaired glucose tolerance	71.43	67.5	0.700
Dyslipidemia	68.5	65.0	0.701
Hypertension	34.6	42.5	0.250
Fatty liver	44.2	52.5	0.330
Cerebral bleeding	1.5	0	1.000
Cerebral infarction	3.7	0	0.591
Angina pectoris or myocardial infarction	14.8	2.5	0.049
Arteriosclerosis obliterans	24.4	15.0	0.277
Malignant tumor	42.4	20.0	0.010
Consanguineous marriage	39.0	29.7	0.424

The data in this registry in 2020 was compared with the data of survey in 2009. Fisher’s exact test was used for the statistical comparison.