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. 2020 Dec 29;12(24):24940–24956. doi: 10.18632/aging.202441

Table 4. Medications administered changes over time.

In 2009 (%) In 2020 (%) P value
Diabetes, IGT
DPP-4 inhibitor 0 37.0 <0.01
Biguanide 19.1 33.3 0.261
Thiazolidine 40.4 48.1 0.630
alpha GI 25.5 7.4 0.067
Sulfonylurea 29.8 11.1 0.086
SGLT2 inhibitor 0 3.7 0.375
Glinide 4.3 0 0.527
GLP-1 analog 0 3.7 1.000
Insulin 27.7 14.8 0.381
Dyslipidemia
Statin 65.4 65.4 0.610
Fibrate 19.2 3.8 0.017
Ezetimibe 1.9 0 1.000
EPA 5.8 11.5 0.557
Resin 1.9 0 1.000
Nicotinic acid 1.9 19.2 0.153
Probucol 5.8 0 0.503
Hypertension, among others
Ca blocker 42.1 47.1 1.000
ARB 47.4 35.3 0.510
ACE inhibitor 5.3 0.0 1.000
Alpha1 blocker 0.0 0.0 1.000
Beta blocker 5.3 11.8 1.000
Diuretics 10.5 0.0 0.487
Antiplatelet NA 5.0 NA
Anticoagulant NA 12.5 NA

The data in this registry in 2020 was compared with the data of survey in 2009. Fisher’s exact test was used for the statistical comparison.

The percentages of medications administered to treat abnormal glucose metabolism, dyslipidemia, and hypertension are shown for the total number of patients with each disorder. DPP-4, Dipeptidyl peptidase-4; alpha GI, alpha glucosidase inhibitor; SGLT2, Sodium-glucose cotransporter-2; GLP-1, Glucagon-like peptide-1; EPA, Eicosapentaenoic acid; Ca, Calcium; ARB, Angiotensin-II receptor blocker; ACE, Angiotensin-converting enzyme inhibitor, NA; not available.