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. 2020 Dec 29;12(24):24504–24521. doi: 10.18632/aging.202453

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Copyright: © 2020 Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Increased NAD⁺ and SIRT1 levels after retinal detachment (RD) with NMN supplementation. Significant increase of NAD⁺ levels in the NMN-treated detached retinas compared to the vehicle and the attached retinas at 24h (A) and three days (B) after RD. NAD⁺ levels in vehicle-treated detached retinas were not lower compared to untreated controls. N = 8 to 11 eyes per group. (C) Upregulation of SIRT1 protein levels in NMN-treated retinas seen at 24h and 7 days post RD. SIRT1 levels were comparable among groups at three days post RD. N = 3 to 7 eyes per group. Statistical significance was analyzed with one-way ANOVA followed by Tukey-Kramer adjustments. *p<0.05. **p<0.01. ***p<0.001. Data are mean ± SEM.