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. 2020 Dec 9;12(24):25658–25672. doi: 10.18632/aging.104175

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Copyright: © 2020 Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The hsa_circ_0003528 signaling pathway was associated with macrophage polarization induced by IFN-γ + LPS or IL-4 (*P value < 0.05 vs. M (-) group; ** P value < 0.05 vs. M(IFN-γ + LPS) group). (A) The expression of hsa_circ_0003528 in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (B) The expression of miR-224-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (C) The expression of miR-324-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (D) The expression of miR-488-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (E) The expression of CTLA4 mRNA in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group. (F) The expression of CTLA4 protein in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group.