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Schematic of miR-106b impact on CNV in mouse laser burn model. (A) Bruch's membrane disruption following laser burn. (B) Intravitreal injection of LV.shGFP or LV.miR-106b. (C) PERK activation represses miR-106b expression and leads to pro-angiogenic factor overexpression, contributing to CNV formation. (D) Increased expression of miR-106b by LV leads to decreased CNV formation by targeting proangiogenic factor protein production. (CNV: choroidal neovascularization, LV: lentivirus).
