Table 3.

Change from Baseline in Total Cholesterol, LDL-C, HDL-C, and Triglyceride after Pitavastatin Treatment

Variable	All (n=27,901)			1 mg (n=145)			2 mg (n=18,965)			4 mg (n=8,690)
	No.	Mean±SD	P value	No.	Mean±SD	P value	No.	Mean±SD	P value	No.	Mean±SD	P value
Total cholesterol, mg/dL
Baseline	15,377	214.54±52.55	-	110	217.51±55.98	-	10,311	213.70±53.14	-	4,870	216.19±51.17	-
>8 wk	8,615	171.50±36.38	-	91	175.26±35.38	-	5,731	173.69±36.82	-	2,708	166.84±35.01	-
Changea	7,341	−48.24±44.88	<0.0001c	82	−50.01±36.45	<0.0001b	4,881	−44.73±43.99	<0.0001c	2,304	−55.47±45.88	<0.0001c
LDL-C, mg/dL
Baseline	12,672	132.96±44.70	-	93	131.89±40.18	-	8,115	131.64±45.17	-	4,389	135.29±43.79	-
>8 wk	7,059	97.11±31.03	-	73	108.30±26.71	-	4,465	97.90±31.11	-	2,443	95.37±30.95	-
Changea	5,598	−41.71±39.47	<0.0001c	64	−33.34±23.93	<0.0001b	3,474	−39.13±39.46	<0.0001c	1,997	−46.27±39.07	<0.0001c
HDL-C, mg/dL
Baseline	13,174	50.16±14.30	-	55	48.08±10.69	-	8,658	50.55±14.58	-	4,382	49.38±13.77	-
>8 wk	7,178	51.57±14.03	-	38	48.40±9.54	-	4,701	51.79±14.39	-	2,361	51.19±13.36	-
Changea	5,728	0.94±10.99	<0.0001c	25	4.34±7.42	0.0047c	3,694	0.83±11.54	<0.0001c	1,945	1.10±9.94	<0.0001c
Triglyceride, mg/dL
Baseline	14,207	171.90±137.46	-	100	170.04±107.04	-	9,385	170.21±118.31	-	4,640	175.28±169.82	-
>8 wk	7,756	147.76±88.77	-	81	144.83±63.32	-	5,112	148.07±92.83	-	2,483	147.29±80.93	-
Changea	6,368	−31.05±151.54	<0.0001c	68	−27.93±61.22	<0.0001c	4,161	−26.16±109.96	<0.0001c	2,071	−40.54±213.27	<0.0001c

LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; SD, standard deviation.

^aChange: Only the data of subjects who had both baseline and >8 weeks were analyzed;

^bP value: Paired t test;

^cP value: Wilcoxon’s signed rank test.