Table 2.

Subgroup Analysis of the Association between Overt Hyperthyroidism and the Risk of Cardiovascular Events

Subgroup	Pooled HR (95% CI)	I2, %	No. of studies
Ischemic heart disease
Age group
<65 yr	1.11 (1.03–1.19)	0	4
≥65 yr	NA	-	-
CVD risk group
High	NA	-	-
Low	1.11 (1.03–1.19)	0	4
Stroke
Age group
<65 yr	1.38 (1.06–1.78)	54.2	10
≥65 yr	0.64 (0.18–2.26)	-	1
CVD risk
High (with A-fib)	2.05 (0.21–20.29)	60.7	3
Low	1.19 (1.13–1.25)	35.5	8
Heart failure
Age group
<65 yr	1.42 (0.93–2.16)	90.6	2
≥65 yr	NA	-	-
CVD risk group
High	NA	-	-
Low	1.42 (0.93–2.16)	90.6	2
CV mortality
Age group
<65 yr	1.16 (0.93–1.45)	76.4	6
≥65 yr	1.46 (1.20–1.77)	-	1
CVD risk group
High	-	-	-
Low	1.20 (1.00–1.46)	76.3	7

HR, hazard ratio; CI, confidence interval; NA, not available; CVD, car-diovascular disease; A-fib, atrial fibrillation.