Table 3.
Subgroup Analysis of the Association between Subclinical Hyperthyroidism and the Risk of Cardiovascular Events
| Subgroup | Pooled HR (95% CI) | I2, % | No. of studies |
|---|---|---|---|
| Ischemic heart disease | |||
| Age group | |||
| <65 yr | 1.27 (1.06–1.53) | 0 | 7 |
| ≥65 yr | 1.17 (0.88–1.55) | 0 | 4 |
| CVD risk group | |||
| High | 1.32 (0.98–1.77) | 16.7 | 4 |
| Low | 1.22 (1.02–1.45) | 0 | 7 |
|
| |||
| Stroke | |||
| Age group | |||
| <65 yr | 1.25 (0.92–1.70) | 0 | 2 |
| ≥65 yr | 1.12 (0.13–9.93) | 68.6 | 3 |
| CVD risk | |||
| High | 1.48 (0.32–6.84) | 81 | 2 |
| Low | 1.16 (0.87–1.55) | 0 | 3 |
|
| |||
| Heart failure | |||
| Age group | |||
| <65 yr | 1.52 (0.86–2.69) | - | 1 |
| ≥65 yr | 1.40 (0.27–7.34) | 75.2 | 3 |
| CVD risk group | |||
| High | 1.73 (0.56–5.36) | 86.9 | 2 |
| Low | 1.24 (0.81–1.92) | 12.9 | 2 |
|
| |||
| CV mortality | |||
| Age group | |||
| <65 yr | 1.34 (0.61–2.94) | 67 | 6 |
| ≥65 yr | 0.99 (0.79–1.25) | 18.7 | 9 |
| CVD risk group | |||
| High | 1.26 (0.40–3.91) | 74.7 | 5 |
| Low | 1.26 (1.00–1.59) | 14.1 | 10 |
HR, hazard ratio; CI, confidence interval; NA, not available; CVD, cardiovascular disease.