Table 1.
Clinical Characteristics of Study Participants
| Characteristic | Discovery set (Ansung cohort) | Validation set (GENIE cohort) | ||||
|---|---|---|---|---|---|---|
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| Total (n=2,451) | Men (n=1,000) | Women (n=1,451) | Total (n=2,733) | Men (n=949) | Women (n=1,784) | |
| Age, yr | 62.6±10.6 | 62.7±10.4 | 62.5±10.7 | 51.1±8.4a | 54.6±8.5a | 49.2±7.8a |
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| Female sex | 1,451 (59.2) | - | - | 1,784 (65.3)a | - | - |
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| BMI, kg/m2 | 24.3±3.3 | 23.7±3.0 | 24.7±3.4 | 22.7±2.9a | 24.3±2.4 | 21.8±2.7a |
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| Lumbar spine BMD, g/cm2 | 1.007±0.194 | 1.090±0.185 | 0.952±0.180 | 1.184±0.170a | 1.156±0.160a | 1.237±0.174a |
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| Femur neck BMD, g/cm2 | 0.834±0.146 | 0.897±0.143 | 0.790±0.131 | 0.879±0.119 | 0.865±0.113 | 0.921±0.127a |
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| Total hip BMD, g/cm2 | 0.899±0.154 | 0.965±0.144 | 0.853±0.144 | 0.945±0.127 | 0.924±0.119 | 1.012±0.129a |
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| Trabecular bone score | 1.406±0.112 | 1.432±0.098 | 1.388±0.117 | 1.415±0.068 | 1.433±0.071 | 1.405±0.064a |
Values are expressed as mean±standard deviation or number (%).
GENIE, Gene-Environment Interaction and Phenotype; BMI, body mass index; BMD, bone mineral density.
a
P<0.05 using Student t test between discovery and validation set.