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. 2021 Jan 4;24(1):101975. doi: 10.1016/j.isci.2020.101975

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Downregulation of IL-18R during SG and SI-IEL Trm differentiation

Similar experimental setup to Figure 1. Day 25 (A) or day 45 (B) post-infection, SG P14 (upper row) and SI-IEL P14 (lower row) were isolated and subjected to flow cytometry analysis. Donor P14 T cells were first gated based on the expression of CD69 and IL-18R. The expression of Ly6C (left) and CD103 (right) on each subset were shown. Each group of connected symbols in (A) represents the results from an individual animal. ∗, p < 0.05; ∗∗∗, p < 0.001; and ∗∗∗∗, p < 0.0001 by one-way ANOVA with Tukey multi-comparison post-test. See also Figures S1 and S2.