Table 2.
The association between month of vaccination and BCG-scar prevalence 13 month after neonatal BCG vaccination among 2039 BCG-vaccinated in the Danish Calmette Study.
| Determinants | (+) BCG, N = 2118 |
Data for scars |
Crude (N = 2039) |
Adjusted∗ (N = 1968) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Number of Infants (%) | Number of infants with scar information (2039), (% with information) | No scar | Scar (%) | Prevalence ratio (95% CI) | p-value | Prevalence ratio (95% CI) | p-value | ||
| Month of vaccination | January | 190 (9) | 188 (99) | 13 | 175 (93) | 1 (ref.) | 1 (ref.) | ||
| February | 166 (8) | 162 (98) | 11 | 151 (93) | 1.00 (0.95–1.06) | 0.96 | 1.01 (0.95–1.08) | 0.68 | |
| March | 179 (8) | 174 (97) | 5 | 169 (97) | 1.04 (1.00–1.09) | 0.07 | 1.02 (0.97–1.07) | 0.43 | |
| April | 158 (7) | 152 (96) | 7 | 145 (95) | 1.02 (0.97–1.08) | 0.92 | 0.94 (0.87–1.00) | 0.07 | |
| May | 158 (7) | 156 (99) | 5 | 151 (97) | 1.04 (0.99–1.09) | 0.11 | 0.91 (0.84–0.98) | 0.01 | |
| June | 165 (8) | 162 (98) | 7 | 155 (96) | 1.03 (0.98–1.08) | 0.29 | 0.91 (0.84–0.99) | 0.02 | |
| July | 177 (8) | 171 (97) | 25 | 146 (85) | 0.92 (0.85–0.99) | 0.02 | 0.81 (0.74–0.90) | 0.00 | |
| August | 178 (8) | 170 (96) | 15 | 155 (91) | 0.98 (0.92–1.04) | 0.51 | 0.87 (0.80–0.94) | 0.00 | |
| September | 158 (7) | 156 (99) | 7 | 149 (96) | 1.03 (0.97–1.08) | 0.33 | 0.89 (0.82–0.96) | 0.01 | |
| October | 196 (9) | 186 (95) | 31 | 155 (83) | 0.90 (0.83–0.97) | 0.00 | 0.82 (0.75–0.90) | 0.00 | |
| November | 227 (11) | 206 (91) | 41 | 165 (80) | 0.86 (0.80–0.93) | 0.00 | 0.87 (0.81–0.95) | 0.00 | |
| December | 166 (8) | 156 (94) | 15 | 141 (90) | 0.97 (0.91–1.04) | 0.37 | 0.98 (0.92–1.04) | 0.44 | |
∗
Analysis adjusted for study site, vaccine batch, vaccine experience, maternal age at delivery, maternal BCG vaccination, parental smoking, atopic disposition, other children <4 years of age in the home, sex, prematurity, birth weight, caesarean section, child age at BCG vaccination, ethnicity, exclusively breastfeed, mid-upper arm circumference and Δweight.