Table 1.
Changes in biochemical parameters after treatment with Le Carbone in NASH-HCC mice.
| Normal group (n = 6) |
NASH group (n = 6) |
NASH + LC group (n = 6) |
|
|---|---|---|---|
| Food intake/day/mouse (g) | 3.133 ± 0.151 | 2.575 ± 0.053 | 2.505 ± 0.154 |
| EC/day/mouse (Kcal) | 12.66 ± 0.611 | 13.1 ± 0.27 | 12.72 ± 0.783 |
| Body weight (BW) (g) | 24.23 ± 0.75 | 22.70 ± 4.66 | 22.33 ± 1.62 |
| Liver index (LW)/BW (g/Kg) | 53.48 ± 2.61 | 86.85 ± 14.32∗∗ | 63.33 ± 11.29# |
| Blood glucose (mg/dL) | 110.75 ± 13.67 | 469.60 ± 65.00∗∗∗ | 490.50 ± 14.18∗∗∗ |
| Serum TG (mg/dL) | 47.33 ± 13.8 | 59.00 ± 18.33 | 30.50 ± 13.53 |
| Serum TC (mg/dL) | 90.00 ± 7.81 | 202.00 ± 29.02∗∗∗ | 148.50 ± 19.94#∗ |
| Serum ALT (IU/L) | 62.00 ± 3.46 | 367.00 ± 173.53∗ | 65.75 ± 27.29# |
| Serum AST (IU/L) | 145.67 ± 46.29 | 799.25 ± 353.26∗ | 186.00 ± 66.39# |
| Serum ALP (IU/L) | 358.33 ± 35.84 | 646.25 ± 215.13 | 334.25 ± 89.20# |
Normal, age matched normal mice; NASH, untreated NASH-HCC mice; NASH + LC, NASH-HCC mice treated with Le Carbone suspension at 5 mg/mouse/day. TG: triglyceride; TC: total cholesterol, ALT: alanine aminotransferase, ALP: alkaline phosphatase, AST: aspartate aminotransferase, EC: Energy consumption. Values are expressed as means ± SEM∖. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 vs normal, #p < 0.05 vs NASH.