TABLE 3.
Hemodynamic Parameters and Vasoactive Drugs
| Parameter | IV Before Isoflurane (260 d) | Isoflurane (506 d) | IV After Isoflurane (204 d) | p |
|---|---|---|---|---|
| Mean arterial pressure, mm Hg | 79 ± 14 | 75 ± 13a,b | 80 ± 15 | < 0.001 |
| Heart rate, /min | 92 ± 16 | 99 ± 14a | 101 ± 14a | < 0.001 |
| Central venous pressure, mm Hg | 11 ± 4 | 11 ± 3 | 11 ± 3 | 0.080 |
| Mean pulmonary arterial pressure, mm Hg | 29 ± 6 | 28 ± 6b | 30 ± 6 | 0.027 |
| Cardiac output, L/min | 7.9 ± 1.8 | 8.5 ± 1.9a,b | 8.0 ± 1.8 | < 0.001 |
| Vasoactive drugs, No. of days (%) | 115 (44.2%) | 162 (32%) | 59 (28.9%) | < 0.001 |
| Dopamine, µg/kg/min | 5.7 ± 2.5 | 10.7 ± 8.1 | 12.7 ± 7.4 | 0.790 |
| Norepinephrine, µg/kg/min | 0.12 ± 0.13 | 0.08 ± 0.06a | 0.12 ± 0.17 | 0.001 |
| Dobutamine, µg/kg/min | 5.0 ± 3.1 | 4.1 ± 1.9b | 2.6 ± 1.6a | < 0.001 |
| Antihypertensive agents, No. of days (%) | 8 (3.1%) | 12 (2.4%) | 16 (7.8%) | 0.004 |
ap < 0.05 vs IV before isoflurane.
bp < 0.05 vs IV after isoflurane.
Data are expressed as mean ± sd, median (interquartile range), and absolute (relative, % of the step) frequency.