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. 2021 Jan 12;11:754. doi: 10.1038/s41598-020-80254-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative reflectance confocal images of in vivo mouse ear tissue at (a) 25 °C and (b) 60 °C. Confocal videos of in vivo mouse ear tissue at 25 °C, and heated to 60 °C, are shown in Supplemental Videos S1 and S2, respectively. Dashed arrows and dotted arrows point to a vascular wall and erythrocytes inside the vessel, respectively. Solid arrows points to a hair follicle. FOV = 750 µm × 560 µm.