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Canagliflozin ameliorated endothelium-dependent vasodilation in diabetic ApoE−/− mice
(A) After 8 weeks of treatment with canagliflozin, the vascular response to Ach was ameliorated in canagliflozin-treated diabetic ApoE−/− mice compared with the nontreated group. (B) There was no difference in vascular response to SNP between the treated group and nontreated group (n = 10–16, per group). *; P < 0.05. All values are mean ± SEM.
