Supplemental Table 7. Absolute value and percent change for particle size in 20 subclasses by presence/absence of diabetes mellitus.
|
A. Baseline | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sub class 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |
| DM | ||||||||||||||||||
| Measured value, nM | ||||||||||||||||||
| Placebo | 4.19 ± 3.05 | 13.55 ± 8.04 | 38.23 ± 13.47 | 45.32 ± 15.13 | 41.35 ± 12.26 | 187.97 ± 42.70 | 523.83 ± 116.26 | 300.81 ± 92.55 | 105.37 ± 33.07 | 24.49 ± 8.77 | 35.97 ± 8.61 | 32.56 ± 10.08 | 158.14 ± 56.94 | 1182.07 ± 563.61 | 4076.83 ± 769.97 | 5480.36 ± 755.65 | 2940.53 ± 466.21 | 1401.30 ± 271.89 |
| Evolocumab | 3.68 ± 3.00 | 12.39 ± 8.01 | 37.80 ± 13.75 | 47.98 ± 17.93 | 40.92 ± 12.21 | 190.87 ± 39.11 | 534.10 ± 122.54 | 302.18 ± 96.23 | 104.41 ± 30.61 | 24.82 ± 9.64 | 36.75 ± 7.51 | 34.07 ± 10.73 | 182.76 ± 99.03 | 1381.58 ± 823.70 | 4266.91 ± 818.21 | 5593.25 ± 798.69 | 2949.88 ± 415.11 | 1449.89 ± 287.56 |
| Non-DM | ||||||||||||||||||
| Measured value, mg/dL | ||||||||||||||||||
| Placebo | 3.54 ± 2.79 | 11.84 ± 7.82 | 36.74 ± 15.04 | 45.21 ± 17.16 | 40.55 ± 13.92 | 192.98 ± 48.60 | 536.99 ± 126.86 | 305.00 ± 87.17 | 106.31 ± 29.89 | 24.45 ± 9.96 | 36.66 ± 8.33 | 34.88 ± 11.52 | 185.71 ± 89.89 | 1512.68 ± 826.09 | 4430.74 ± 1002.95 | 5616.93 ± 797.03 | 3015.39 ± 446.55 | 1470.70 ± 262.02 |
| Evolocumab | 4.03 ± 3.87 | 13.55 ± 10.73 | 39.77 ± 18.72 | 48.00 ± 19.41 | 41.81 ± 14.86 | 200.75 ± 60.22 | 565.56 ± 167.71 | 320.57 ± 107.93 | 111.19 ± 36.98 | 25.96 ± 9.23 | 37.81 ± 9.44 | 33.44 ± 11.06 | 180.05 ± 101.68 | 1346.29 ± 844.98 | 4130.88 ± 963.79 | 5493.11 ± 808.75 | 2980.48 ± 442.74 | 1456.65 ± 263.70 |
|
B. Week 12 | ||||||||||||||||||
| Sub class 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DM | ||||||||||||||||||
| Measured value, nM | ||||||||||||||||||
| Placebo | 4.02 ± 3.47 | 13.19 ± 9.65 | 37.71 ± 15.04 | 45.77 ± 15.68 | 41.32 ± 10.96 | 186.14 ± 43.13 | 520.53 ± 116.21 | 304.61 ± 96.98 | 107.09 ± 35.63 | 25.26 ± 10.00 | 36.25 ± 9.38 | 33.18 ± 10.01 | 155.05 ± 57.29 | 1178.62 ± 607.35 | 4026.43 ± 873.29 | 5397.20 ± 770.86 | 2929.25 ± 438.73 | 1415.72 ± 249.40 |
| Evolocumab | 2.55 ± 2.12 | 8.77 ± 5.82 | 20.90 ± 10.52 | 29.45 ± 12.62 | 23.50 ± 6.61 | 77.91 ± 22.66 | 183.80 ± 65.08 | 106.50 ± 44.92 | 37.69 ± 14.33 | 12.79 ± 4.73 | 19.56 ± 5.09 | 27.28 ± 10.16 | 182.90 ± 104.32 | 1601.74 ± 864.66 | 4618.65 ± 896.90 | 5600.32 ± 795.47 | 2928.71 ± 423.75 | 1391.88 ± 273.16 |
| Change from baseline, % | ||||||||||||||||||
| Placebo | −13.33 (−38.67, 31.91) | −13.53 (−32.94, 30.35) | −2.85 (−20.02, 17.36 | 1.82 (−12.59, 14.47) | 2.20 (−11.56, 16.15) | −1.59 (−10.52, 10.28) | −1.15 (−10.40, 10.03) | 2.64 (−10.69, 12.72) | 2.82 (−10.36, 12.76) | 2.46 (−11.77, 13.06) | 0.00 (−7.99, 10.36) | 4.03 (−10.07, 15.27) | −0.41 (−10.58, 12.74) | 3.78 (−17.26, 20.45) | −0.88 (−9.75, 7.29) | −1.12 (−7.05, 4.35) | −0.38 (−9.13, 9.38) | 1.41 (−7.40, 10.67) |
| Evolocumab | −33.49 (−57.69, 6.96) | −31.22 (−50.26, −0.87) | −47.87 (−57.20, −34.39) | −37.93 (−52.80, −21.98) | −41.96 (−51.82, −31.07) | −60.43 (−65.19, −53.30) | −68.33 (−72.90, −57.64) | −66.54 (−72.86, −56.30) | −64.86 (−71.97, −55.07) | −48.20 (−57.76, −36.27) | −47.87 (−55.61, −38.84) | −22.38 (−35.32, −5.65) | −4.48 (−12.42, 14.74) | 18.19 (−1.22, 38.78) | 8.26 (−1.39, 17.87) | 0.61 (−5.25, 6.95) | −0.44 (−8.46, 6.87) | −4.84 (−11.45, 2.43) |
| Non-DM | ||||||||||||||||||
| Measured value, mg/dL | ||||||||||||||||||
| Placebo | 3.56 ± 2.83 | 11.95 ± 8.23 | 37.05 ± 16.18 | 46.27 ± 18.06 | 40.38 ± 12.64 | 190.32 ± 49.12 | 535.91 ± 125.08 | 308.69 ± 96.91 | 107.25 ± 33.58 | 24.04 ± 9.40 | 36.50 ± 8.37 | 34.10 ± 9.87 | 190.66 ± 92.32 | 1539.99 ± 835.43 | 4357.70 ± 998.02 | 5518.06 ± 720.85 | 2966.18 ± 402.08 | 1475.64 ± 254.11 |
| Evolocumab | 2.69 ± 3.22 | 8.98 ± 7.86 | 21.43 ± 12.67 | 28.40 ± 13.26 | 23.41 ± 8.45 | 82.24 ± 36.47 | 201.11 ± 111.65 | 117.32 ± 65.76 | 41.77 ± 22.82 | 13.87 ± 6.33 | 20.76 ± 7.18 | 28.31 ± 12.18 | 190.92 ± 117.66 | 1677.04 ± 954.60 | 4544.89 ± 964.35 | 5433.09 ± 786.30 | 2928.84 ± 440.71 | 1397.33 ± 317.63 |
| Change from baseline, % | ||||||||||||||||||
| Placebo | 0.39 (−32.08, 33.81) | −1.20 (−30.05, 35.25) | 3.10 (−14.08, 18.36) | 2.16 (−11.30, 16.93) | −0.52 (−12.64, 18.28) | −0.90 (−11.12, 8.16) | 1.61 (−7.53, 9.54) | 1.94 (−8.55, 12.74) | 1.42 (−10.95, 12.08) | −0.14 (−10.32, 11.75) | −1.30 (−6.88, 9.79) | 0.03 (−10.35, 9.90) | 3.52 (−12.13, 17.89) | 0.87 (−8.90, 15.12) | −1.71 (−8.28, 6.76) | −0.98 (−7.36, 4.84) | −1.79 (−8.87, 6.06) | −0.52 (−7.21, 9.21) |
| Evolocumab | −37.44 (−61.81, −8.10) | −33.81 (−53.44, −10.43) | −47.80 (−62.31, −35.31) | −41.44 (−56.17, −28.96) | −43.57 (−52.37, −32.70) | −58.53 (−67.71, −52.06) | −65.36 (−72.91, −57.38) | −63.89 (−72.03, −55.41) | −63.45 (−71.06, −54.60) | −47.40 (−57.04, −35.82) | −45.90 (−52.91, −38.00) | −14.43 (−33.47, −1.43) | 2.71 (−12.64, 18.17) | 30.20 (8.80, 45.76) | 9.58 (1.51, 19.23) | −0.26 (−7.21, 6.01) | −0.98 (−11.21, 7.82) | −4.18 (−10.02, 5.29) |
|
C. Mean of weeks 10 and 12 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sub class 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |
| DM | ||||||||||||||||||
| Measured value, nM | ||||||||||||||||||
| Placebo | 3.97 ± 2.89 | 12.99 ± 8.12 | 37.30 ± 13.23 | 45.56 ± 15.45 | 40.91 ± 10.50 | 182.80 ± 39.25 | 509.30 ± 107.36 | 298.45 ± 92.59 | 104.96 ± 34.11 | 25.11 ± 9.64 | 35.74 ± 8.83 | 32.68 ± 9.27 | 154.14 ± 54.11 | 1170.31 ± 570.60 | 3990.64 ± 823.72 | 5377.22 ± 742.80 | 2915.11 ± 420.86 | 1405.45 ± 243.42 |
| Evolocumab | 2.41 ± 1.72 | 8.19 ± 4.66 | 19.57 ± 8.61 | 28.27 ± 11.33 | 22.84 ± 6.55 | 73.60 ± 21.56 | 166.79 ± 57.73 | 95.40 ± 37.65 | 34.02 ± 12.23 | 12.10 ± 4.18 | 18.72 ± 4.94 | 27.32 ± 10.03 | 183.05 ± 106.87 | 1601.94 ± 843.94 | 4563.74 ± 823.49 | 5495.60 ± 737.16 | 2871.66 ± 391.40 | 1356.90 ± 261.14 |
| Change from baseline, % | ||||||||||||||||||
| Placebo | −5.59 (−32.52, 36.32) | −8.64 (−27.34, 19.48) | −4.42 (−17.04, 14.65) | 2.49 (−13.32, 14.48) | −0.57 (−11.59, 11.15) | −2.86 (−11.18, 6.90) | −2.66 (−9.90, 6.18) | −0.39 (−9.66, 9.41) | −1.33 (−10.12, 9.56) | 1.57 (−7.23, 12.47) | −0.19 (−7.29, 6.93) | 0.51 (−7.92, 12.87) | −2.42 (−10.60, 9.61) | 1.25 (−12.64, 16.87) | −0.82 (−8.90, 6.02) | −2.23 (−6.45, 3.94) | −1.50 (−7.70, 6.23) | 0.98 (−5.81, 7.54) |
| Evolocumab | −31.15 (−56.47, −3.10) | −30.45 (−51.00, −8.11) | −47.94 (−57.29, −38.15) | −40.55 (−50.05, −30.23) | −43.70 (−52.19, −33.81) | −62.13 (−68.18, −55.74) | −70.35 (−75.76, −61.81) | −68.26 (−74.77, −62.40) | −67.12 (−74.24, −61.12) | −50.35 (−59.87, −39.57) | −48.50 (−58.19, −41.23) | −22.51 (−32.87, −9.07) | 0.02 (−12.66, 11.91) | 20.28 (2.73, 34.68) | 7.04 (0.04, 14.95) | −1.51 (−6.16, 4.09) | −3.01 (−8.95, 4.76) | −7.68 (−12.34, −0.17) |
| Non-DM | ||||||||||||||||||
| Measured value, mg/dL | ||||||||||||||||||
| Placebo | 3.54 ± 2.47 | 11.81 ± 7.01 | 36.90 ± 14.06 | 45.92 ± 16.41 | 40.18 ± 12.23 | 188.48 ± 48.22 | 527.42 ± 120.85 | 304.12 ± 91.46 | 106.09 ± 31.22 | 24.10 ± 9.04 | 36.33 ± 8.03 | 34.11 ± 9.72 | 188.11 ± 90.96 | 1499.10 ± 805.92 | 4299.24 ± 935.90 | 5484.87 ± 686.25 | 2958.55 ± 364.34 | 1464.19 ± 221.75 |
| Evolocumab | 2.61 ± 2.70 | 8.66 ± 6.67 | 20.64 ± 11.28 | 27.59 ± 12.06 | 22.90 ± 8.05 | 77.90 ± 34.07 | 183.93 ± 101.12 | 106.34 ± 59.66 | 37.97 ± 20.10 | 13.09 ± 5.73 | 19.80 ± 6.44 | 27.32 ± 11.15 | 187.65 ± 111.49 | 1646.41 ± 921.96 | 4510.62 ± 937.74 | 5352.26 ± 700.67 | 2861.28 ± 415.57 | 1358.20 ± 276.74 |
| Change from baseline, % | ||||||||||||||||||
| Placebo | 0.72 (−30.95, 40.83) | 6.89 (−26.92, 36.16) | 1.45 (−14.77, 21.65) | 1.62 (−8.84, 17.03) | 1.63 (−13.67, 15.53) | −2.23 (−11.71, 6.45) | −0.89 (−8.43, 5.19) | 1.36 (−9.93, 9.98) | 1.63 (−10.79, 10.72) | 0.35 (−10.29, 12.44) | 0.62 (−8.28, 7.59) | −0.09 (−8.12, 8.55) | 1.99 (−8.71, 12.59) | 0.40 (−8.20, 9.80) | −2.37 (−9.41, 2.57) | −2.18 (−7.83, 3.47) | −2.44 (−6.76, 6.05) | −0.27 (−7.71, 6.87) |
| Evolocumab | −35.81 (−56.93, −2.09) | −35.19 (−53.10, −7.31) | −50.45 (−59.96, −37.50) | −44.47 (−53.72, −32.99) | −45.31 (−52.86, −35.96) | −63.49 (−67.94, −55.26) | −69.26 (−74.30, −63.03) | −69.19 (−73.42, −60.48) | −67.78 (−72.93, −59.48) | −48.93 (−58.68, −39.70) | −47.95 (−56.95, −40.48) | −18.48 (−31.23, −6.03) | 0.79 (−11.20, 15.31) | 25.61 (10.32, 44.19) | 8.96 (1.91, 18.36) | −2.17 (−8.21, 4.23) | −3.71 (−11.32, 5.81) | −8.25 (−13.56, 2.59) |
Abbreviation: DM, diabetes mellitus. Data are expressed as mean ± SD or median (interquartile range).