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. 2020 Nov 11;92(1):86–95. doi: 10.1136/jnnp-2020-322983

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Neuropathological hallmarks of TDP-43 proteinopathies as observed with TDP-43 immunohistochemistry. (A) An alpha motor neuron in the cervical spinal cord of a patient with amyotrophic lateral sclerosis (ALS) demonstrating intraneuronal cytoplasmic inclusions of TDP-43 (black arrows) and nuclear clearance (nucleus stained blue, red arrow). (B) Intraneuronal cytoplasmic aggregates (black arrow) and nuclear clearance (nucleus stained blue, red arrow) in a neuron of the inferior olivary nucleus. (C) Glial coiled body-like inclusions (blue arrow) in the caudal pons. All images represent light microscopy micrographs obtained at ×400 magnification (University of Newcastle). The antibody used was the proteintech antibody (Proteintech, rabbit polyclonal; product code 1072-2-AP). All images are derived from patients with sporadic ALS.