Figure 4.

Associations between regional [¹¹C]PK11195 binding and hypertensive arteriopathy (n=42). (A) β-weight brain mapping of associations between regional [¹¹C]PK11195 binding and hypertensive arteriopathy. Coloured overlay of the Hammers atlas represents statistically significant elevation of [¹¹C]PK11195 binding with hypertensive arteriopathy score controlling for sex, age, education, ACE-R score and scan interval and corrected for multiple comparisons. Colour gradient represents the strength of association (standardised β weights), increasing in magnitude from light blue to fuchsia. (B) Scatterplots of relationships between hypertensive arteriopathy (y-axis) and [¹¹C]PK11195 binding in key regions of interest (x-axis). Hypertensive arteriopathy values are residuals, adjusted for sex, age, education, ACE-R and scan interval. ACE-R, Addenbrooke’s Cognitive Examination-Revised; SVD, small vessel disease.