Table 4.
Diagnostic Clinical Data Including Functional Class, 6MWD, and Right Heart Catheterization Parameters According to WHO Group 1 as Documented on Enrollment in the PAH Biobank
| Characteristic | All Patients | IPAH | FPAH | PVOD/PCH | APAH (All Subgroups) | P Valuea |
|---|---|---|---|---|---|---|
| Functional class | N = 498 | n = 217 | n = 22 | n = 3 | n = 256 | .72 |
| I | 16 (3.2) | 7 (3.2) | 0 | 0 | 9 (3.5) | |
| II | 114 (22.9) | 49 (22.6) | 6 (27.3) | 0 | 59 (23) | |
| III | 225 (45.2) | 97 (44.7) | 5 (22.7) | 1 (33.3) | 122 (47.7) | |
| IV | 41 (8.2) | 18 (8.3) | 5 (22.7) | 1 (33.3) | 17 (6.6) | |
| Indeterminate | 2 (0.4) | 0 | 0 | 0 | 2 (0.8) | |
| Not available | 100 (20.1) | 46 (21.2) | 6 (27.3) | 1 (33.3) | 47 (18.4) | |
| 6MWD, m | 339.5 ± 117.4 | 348.1 ± 122.8 | 411.2 ± 124.1 | 295.5 ± 88.6 | 326.2 ± 109.8 | .09 |
| No. | 381 | 165 | 18 | 3 | 195 | |
| MAP, mm Hg | 93.2 ± 17.4 | 93.5 ± 18.9 | 89.3 ± 12.0 | 94.0 ± NA | 93.4 ± 16.9 | .50 |
| No. | 241 | 97 | 15 | 1 | 128 | |
| Mean PAP, mm Hg | 49.4 ± 13.2 | 51.7 ± 13.5 | 54.8 ± 12.4 | 51.7 ± 14.3 | 46.9 ± 12.5 | .0003 |
| No. | 498 | 217 | 22 | 3 | 256 | |
| PCWP, mm Hg | 10.2 ± 3.8 | 9.9 ± 3.5 | 9.0 ± 3.5 | 13.7 ± 4.9 | 10.4 ± 4.1 | .16 |
| No. | 487 | 214 | 21 | 3 | 249 | |
| Mean RAP, mm Hg | 9.3 ± 5.6 | 9.7 ± 6.0 | 7.5 ± 4.1 | 9.0 ± 4.0 | 9.2 ± 5.3 | .57 |
| No. | 489 | 212 | 22 | 3 | 252 | |
| PVR, Wood units | 10.4 ± 5.8 | 11.1 ± 5.8 | 13.4 ± 6.4 | 6.4 ± 1.6 | 9.7 ± 5.6 | .01 |
| No. | 479 | 210 | 20 | 3 | 246 | |
| Thermodilution cardiac output, L/min | 4.5 ± 1.6 | 4.3 ± 1.4 | 4.2 ± 1.0 | NA | 4.7 ± 1.7 | .04 |
| No. | 291 | 129 | 10 | 0 | 152 | |
| Thermodilution cardiac index, L/min/m2 | 2.4 ± 0.7 | 2.3 ± 0.7 | 2.4 ± 0.7 | NA | 2.6 ± 0.8 | .01 |
| No. | 222 | 101 | 8 | 0 | 113 | |
| Fick cardiac output, L/min | 4.3 ± 1.6 | 4.2 ± 1.5 | 4.0 ± 1.3 | 6.0 ± 0.5 | 4.4 ± 1.6 | .15 |
| No. | 398 | 177 | 19 | 3 | 199 | |
| Fick cardiac index, L/min/m2 | 2.3 ± 0.7 | 2.2 ± 0.7 | 2.0 ± 0.6 | 2.8 ± 0.4 | 2.4 ± 0.8 | .01 |
| No. | 316 | 140 | 16 | 3 | 157 | |
| Svo2, % | 64.0 ± 9.8 | 62.7 ± 8.6 | 64.8 ± 9.9 | 75.4 ± 5.1 | 65.0 ± 10.7 | .05 |
| No. | 289 | 128 | 16 | 2 | 143 |
Data are presented as No. (%) or mean ± SD unless otherwise indicated. 6MWD = 6-min walk distance; MAP = mean arterial pressure; NA = not applicable; PAP = pulmonary artery pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; Svo2 = mixed venous oxygen saturation. See Table 1 and 3 legends for expansion of other abbreviations.
The P value was obtained from the χ2 or Wilcoxon rank sum test examining the difference in the distribution of the characteristic among patients diagnosed with IPAH vs patients diagnosed with APAH.