Table 4.

Summary of imputation studies of top 21 SNPs in trend tests.

Chr	SNP	Position	Gene	Allele 1	Allele 2	Risk Allele	RAF controls	RAF cases	Imputation Trend P	OR	95% CI
1	rs12566078	113,847,571	–	A	G	G	0.8333	0.9643	2.50E−06	5.4	2.51	11.62
4	rs13126673	128,586,241	INTU	T	C	C	0.4531	0.6667	4.15E−06	2.414	1.64	3.552
9	rs10733369	2,122,486	SMARCA2	T	C	C	0.4427	0.6548	9.08E−06	2.387	1.624	3.51
9	rs10733553	9,709,405	–	A	G	G	0.6105	0.808	9.38E−06	2.685	1.748	4.123
10	rs10822312	66,314,543	–	T	G	G	0.6042	0.8333	1.80E−07	3.276	2.11	5.085
20	rs58961824	6,084,195	FERMT1	T	A	A	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs60811855	6,084,782	FERMT1	C	T	T	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs58790452	6,084,920	FERMT1	G	A	A	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs61527455	6,085,639	FERMT1	A	G	G	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs59849941	6,085,718	FERMT1	G	A	A	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs4407314	6,088,005	FERMT1	A	G	G	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs16991857	6,088,993	FERMT1	G	A	A	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs11908294	6,089,741	FERMT1	T	C	C	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs2326719	6,093,090	FERMT1	A	G	G	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs4300912	6,093,624	FERMT1	T	C	C	0.4632	0.676	5.85E−06	2.418	1.639	3.569
20	rs4419295	6,094,060	FERMT1	G	A	A	0.4635	0.6746	5.78E−06	2.399	1.629	3.534
20	rs75911461	6,096,872	FERMT1	T	A	A	0.4579	0.6746	3.37E−06	2.454	1.664	3.62
20	rs117103253	6,097,080	FERMT1	T	A	A	0.4579	0.6746	3.37E−06	2.454	1.664	3.62
20	rs58991632	6,098,405	FERMT1	A	G	G	0.4521	0.6746	1.92E−06	2.512	1.701	3.71
20	rs2273422	6,100,241	FERMT1	G	A	A	0.4521	0.6734	2.42E−06	2.498	1.69	3.694
20	rs2273421	6,100,367	FERMT1	C	T	T	0.4521	0.668	4.32E−06	2.438	1.648	3.608

RAF risk allele frequency, Trend P P vale of Trend test, OR odds ratio, CI confidence interval.