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. 2021 Jan 12;12:304. doi: 10.1038/s41467-020-20556-8

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Diagram displaying proteins that are commonly and exclusively expressed in slow- and fast-twitch muscle fibers + the number of exercise training-regulated proteins in the exclusive population. b Volcano plot comparing fold change (POST vs. PRE) between slow- and fast-twitch muscle fibers. Differently regulated proteins (significance score ≤0.05; paired linear model with Xiao correction⁷²) are marked in blue (change in fast > slow-twitch fibers) and red (change in slow > fast-twitch fibers). c Scatter plot comparing differences in the log₂-changes (POST vs. PRE) between slow- and fast-twitch fibers. The graph includes 131 fiber-type-specific (interaction) significant proteins with examples of few protein categories. d Overlap of exercise training-regulated proteins between whole-muscle lysate and slow-twitch muscle fibers. e Overlap of exercise training-regulated proteins between whole-muscle lysate and fast-twitch muscle fibers.