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. 2021 Jan 12;11:471. doi: 10.1038/s41598-020-80017-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bar chart showing the distribution of dhfr haplotypes in five Nigerian States. Red colour represents Sokoto State, Yellow represents Kwara State, Purple represents Imo State, Green represents Bayelsa State and Blue represents Adamawa State. The triple mutant haplotype I₅₁R₅₉N₁₀₈ was the most distributed in all five States.