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. 2021 Jan 12;11:845. doi: 10.1038/s41598-020-80909-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Flowchart of the cortical thickness matrix construction. (a) Representation of the M individual anatomic MRI images. (b) During FreeSurfer processing, the cortical surface of the M subjects was extracted. (c) Using the FreeSurfer toolbox, the cortical surfaces were labeled using a reference atlas. (d) The cortical thickness for each structure was calculated as the mean thickness of all vertices defined as belongs to that structure. (e) All mean thickness values for all structures and subjects were organized in an array denoted by T of M rows by N columns.