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DNA damage measurements using agarose gel electrophoresis. (A) Gel images of plasmid DNA treated with various concentrations of CDDP with/without the presence of 10 μM RDM-B (BV10), where the three separate bands from top to bottom represent DNA with single-strand break (SSB), double-strand break (DSB, red dashed square), and intact supercoiled DNA (SC, blue dashed square). The yields of DSB DNA and the amount of SC DNA are shown in (B) and (C), respectively.
